Our study tells us that for people who have a diagnosis of diabetes, stroke or a heart attack it is particularly important to look after their health and ensure they are on the right treatment, to prevent further problems as well as to reduce their dementia risk." We know that many patients actually have a range of conditions. Professor David Llewellyn, Senior Author, Professor of Clinical Epidemiology and Clinical Health at the University of Exeter, said: "Many studies look at the risk of a single condition in relation to dementia, but health is more complex than that. Just over 2,000 had two conditions, and 122 had all three. The team, which included the universities of Glasgow and Michigan, found that nearly 20,000 of the UK Biobank participants they studied had been diagnosed with one of the three conditions. So whatever genetic risk you were born with, you can potentially make a big impact on reducing risk of dementia by looking after heart and metabolic health throughout life." We found that having such heart-related conditions is linked to dementia risk to a greater extent than genetic risk. People who had all three conditions were three times more likely to develop dementia than people who had a high genetic risk.ĭr Xin You Tai, Lead Author and Doctoral Student at University of Oxford, said: "Dementia is a major global issue, with predictions that 135 million worldwide will have the devastating condition by 2050. Within this study population, the researchers found that the more of these three conditions a person had, the higher their risk of dementia. The international research team identified those who had been diagnosed with the cardiometabolic conditions diabetes, stroke, or a heart attack, or any combination of the three, and those who went on to develop dementia. Published in The Lancet Healthy Longevity, the paper looked at data from more than 200,000 people, aged 60 or above, and of European ancestry in UK Biobank. Led by Oxford University and the University of Exeter, the study is among the largest ever to examine the link between several heart-related conditions and dementia, and one of the few to look at the complex issue of multiple health conditions.
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